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Raised cholesterol and the Statin effect

(52 Posts)
Flakesdayout Fri 02-Oct-26 10:58:50

I have looked but cannot find many comments about Bempedoic acid as an alternative to Statins. In the past, due to familial raised cholesterol, I have tried Atorvastatin and Rosuvastatin which caused muscle and joint pain. I am currently taking Ezetimibe which has the same effect alongside upset stomach. As my cholesterol levels have not improved much HDL 1.68 LDL 3.84 giving a total of 6.13 I have now been prescribed Bempedoic acid on its own. Has anyone experience of this and does it work? I have read there can be unpleasant side effects from this so am now quite worried. Having been told by one GP that familial raised cholesterol cannot be successfully lowered by diet alone I wonder what may come next if this doesnt work.

Flakesdayout Sun 04-Oct-26 10:57:51

So it appears that no one yet has come forward to say anything about Bempodiac acid which was the point of my post, so it is obviously not one of the common cholesterol go to's, nevertheless I tried Atorvastatin first and had the joint and muscle aches, and was then put on Rosuvastatin. One GP told me '"what is worse a few aches and pains, or a Stroke", so I persevered for a year. Whilst my cholesterol levels went down nicely the aches were so bad that I went back to a different GP and contacted the Lipid clinic as I was getting nowhere. I came off Statins completely for a month, and the aches stopped but my cholesterol went up to 6.67. Ezetimibe came next. The aches have started again to the point I am going to physio to check if I actually have something wrong with my joints and I have had to cut back on my walking. The upset stomach is so unpredictable, one day fine the next constantly on the loo. Today I have not taken anything, I want my body to get rid of this before I put myself through something else. Good luck to everyone trying out these so called medications.

AuntClarasDoorknobs Sat 03-Oct-26 16:42:08

I’ve taken Atorvastatin for decades. No problem whatsoever, my cholesterol was low, but they do give it to diabetics like me to prevent other problems too. What suits one, as they say. Often the side effects settle with time, and the benefits are well documented.

Silvershadow Sat 03-Oct-26 14:57:26

I’m on my second pack of Atorvastatin. I was very unsure about taking these, put it off as long as I could. So far, no side effects at all. I’m also on blood pressure pills, also started this year.

Luckygirl3 Sat 03-Oct-26 14:50:29

PamelaJ1

Luckygirl you spotted the flaw in my argument!

Sorry!

Suki70 Sat 03-Oct-26 11:14:03

Crazy H I’ve taken Atorvastatin for 10 years with no side effects whatsoever. It keeps my cholesterol below 5.

PamelaJ1 Sat 03-Oct-26 10:53:00

Luckygirl you spotted the flaw in my argument!

Luckygirl3 Sat 03-Oct-26 10:26:43

I’m not bothering to test, just expecting to shuffle off this mortal coil in a couple of years with my care home nest egg intact.

Sounds ideal, but unfortunately the main risk with high cholesterol is stroke and this in the main does not allow you to shuffle off without forking out for care and it can be a miserable long drawn out slide into oblivion, distressing for you and for you loved ones!

Would that we could choose our shuffling off mode!

PamelaJ1 Sat 03-Oct-26 09:56:28

Luckygirl3

Statins are now not the only cholesterol lowering drug. Doctor can advise if you are having problems with them. I am currently on 6 monthly injections of Inclisiran.

How lovely to have a doctor who advises!😂
I am persevering with the Atorvastatin because I have read that it helps if one has lipoproteins in the blood.
They can make the blood ‘sticky’ and be one of the factors in the risk of strokes and heart attacks. My sister has just had a blood test and discovered that she has this . It is genetic, not a lot can be done and it could explain why my dad was the healthiest old man at his funeral!
They don’t test for this on the NHS, she had a private MOT. I’m not bothering to test, just expecting to shuffle off this mortal coil in a couple of years with my care home nest egg intact.

Luckygirl3 Sat 03-Oct-26 09:05:41

Statins are now not the only cholesterol lowering drug. Doctor can advise if you are having problems with them. I am currently on 6 monthly injections of Inclisiran.

Allsorts Sat 03-Oct-26 08:03:15

You are supposed to feel better taking any medication and if after a time you are not surely you would not continue, hopefully alternatives could be made which might suit.
I decided against them. Know people that are on them and they think I will regret it as they feel well on them.

Shinamae Fri 02-Oct-26 21:49:42

I have been on this for about six months, no side-effects at all

Ziplok Fri 02-Oct-26 21:42:49

I think the best advice I can give you is to seek professional medical advice.

Experiences from anyone here is purely relating to their own experience, and may well not be your experience (though, of course, it might be). The majority of us are not medically trained, therefore we cannot possibly say you will experience what any of us might experience, and as we are not medically trained to advise you, my advice to seek medical advice stands.

In addition, even if some of us here are medically trained, the fact that we are not privy to your medical background means that we cannot offer anything but general advice, so, please, seek advice and guidance from those who know your own medical history.

Oreo Fri 02-Oct-26 21:24:49

I think what we can take from this discussion is that muscle pain is a well known side effect of statins but that it won’t affect everyone so the best thing is to try it and see.
If you do get debilitating muscle pain then it isn’t worth taking them to have your quality of life decline in that way.

MiniMoon Fri 02-Oct-26 21:20:37

I've been taking Atorvastatin for over a year now. I have had no side effects except for a bonus one. The pain in my knees reduced considerably and I can walk much further than before starting them.

MayBee70 Fri 02-Oct-26 20:35:06

When my doctor wanted me to go on statins I said I was in enough pain with arthritis and he just said but it would be a ‘different kind of pain’. Great!

Oreo Fri 02-Oct-26 19:48:59

Mum reports that muscle pains seem to arrive with whatever statin she took, and the GP said that they just don’t suit some people.
She was really struggling to walk, came off them and a month later was back to her old energetic self.
That last one was Rosuvastatin.

PamelaJ1 Fri 02-Oct-26 19:34:07

crazyH

PamelaJ - please tell me how Atorvastin effects you ?

I had been taking it for about a year when I started to get diarrhoea. I hadn’t changed my diet so stopped taking it. I did tell my GP who ordered a poo and blood test. All clear.
The Diarrhoea seemed to improve but I decided to try again..just to see. After 2 weeks it seems to be back🤷🏼‍♀️. I’ll give it another couple of weeks then get back to the GP. It’s not as bad as it was but I’m scared it will get worse again.

V3ra Fri 02-Oct-26 19:23:07

crazyH I started taking Atorvastatin 20mg nearly three months ago.
I read the leaflet beforehand and was rather alarmed by all the possible side-effects it described, but can honestly say I've had no problems.
I was told to book a further blood test after three months to monitor its effectiveness. That's booked for the end of November.

Luckygirl3 Fri 02-Oct-26 18:50:46

Ideal range differs from person to person so articles setting figures can be very misleading. For instance, I have had a heart attack and have a stent in an artery. I also have a pacemaker. My ideal cholesterol to aim at will be completely different from a fit young man.

Be guided by your doctor and not by people on the Internet with an axe to grind. Your doctor will be following NHS guidelines based on your individual health situation.

Debs8 Fri 02-Oct-26 18:41:34

When I first started taking Rosuvastatin I had muscle aches. My DO did bloodwork and found that I had an iron deficiency. Since starting an iron supplement the aches are almost gone. I’m in the US. Hope this helps.

Sago Fri 02-Oct-26 18:41:07

Yes I took it ………..not for long.

I had awful side effects, unfortunately I have tried them all now and not one has come without side effects.

I’m sure my GP/pharmacist doesn’t believe me.

crazyH Fri 02-Oct-26 18:29:56

PamelaJ - please tell me how Atorvastin effects you ?

crazyH Fri 02-Oct-26 18:27:01

Today is my first day on statins - Atorvastin 20mg daily. Can someone who is on it, please tell me what are the side effects ?

fancyflowers Fri 02-Oct-26 18:07:35

Please read this by Dr Malcolm Kendrick before you take medication for cholesterol. According to him, a total level of 6.13 falls in the ideal range. He has written other books on the subject which I recommend.

PamelaJ1 Fri 02-Oct-26 16:50:01

Sorry I haven’t been on this so can’t help but I thought I’d bump it up.
I’m struggling with Atorvastatin at the moment.