The researchers analyzed results from 46 previous studies worldwide that investigated the potential link between prenatal acetaminophen use and subsequent NDDs in children. The researchers used the Navigation Guide Systematic Review methodology—a gold-standard framework for synthesizing and evaluating environmental health data—which enabled them to conduct a rigorous, comprehensive analysis that supported evidence of an association between acetaminophen exposure during pregnancy and increased incidence of NDDs.
The researchers noted that while steps should be taken to limit acetaminophen use, the drug is important for treating pain and fever during pregnancy, which can also harm the developing fetus. “We recommend judicious acetaminophen use—lowest effective dose, shortest duration—under medical guidance, tailored to individual risk-benefit assessments, rather than a broad limitation,” they wrote.
It is already known that Paracetamol can cause liver damage and occasionally kidney damage also, so, as with any drug, caution is necessary.
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