For me any travelling - even a day out - means careful preparation for medical supplied.
Firstly, I have an ileostomy and ALWAYS ensure that I have in my normal handbag, two complete changes - should it become necessary. Yesterday (for example), just a coach outing to a theatre to a town - I treated myself to a very lovely berry milk-shake - and then did need a full change in the nearby accessible loo.
For overnight stays, have to take with my CPAP machine and extension lead in case where I am staying does not have electrical point next to the bed. Also really need to have with me for that bed a 'slope' to allow me to sleep with my head raised (my bed at home is adjustable).
Also need night=time items for my hands to help prevent calpal tunnel - along with the many pills, etc.
As I need to travel in an electric wheelchair, this means there is very little room for clothes, so - also need to try to make arrangements to have help with some sort of suitcase.
Trains are wonderful - their Passenger Assistance people are great, have found that not all taxis are wheelchair compliant - and some taxi firms do not have facilities for booking such a taxi in advance - which can be a cause for worry.
I am insistent that I should be as independent as anyone else, but do find going away needs a great deal of forward planning .