sharon62 my late husband also had COPD and lived with full-time oxygen therapy for his last couple of years. I was not aware of any change in background temperament, despite myriad medications. Keep in mind that your husband is likely VERY scared, always being breathless, always feeling you can't get enough air into your lungs, it must be (IS) very distressing. Also, just as he retired, expecting the world to opening up for him. he got a devastating, eventually terminal, diagnosis. He knows it won't get better, only worse. He might need some counselling, he's depressed, maybe? Who wouldn't be? Does he attend a Breathe Easy group? Some hospitals have them, under the auspices of the British Lung Foundation, if you contact the Foundation they'll help you. They'll teach breathing exercises and other useful things. Your husband should also be seeing a specialist nurse, at home, organised by your GP, he/she can give useful suggestions, keep an eye on developments and offer useful support and insights to you. Hope this helps a bit. Good luck!