We have a big house and use all the downstairs rooms but not many upstairs. We have thermostatic radiator valves on all our radiators and those in unused rooms are ser at 1. In occupied rooms they are set at 3..
Hot air rised so heat in downstairs room will go through the ceiling and warm the rooms above them, unless, of course, you have 12 inches of insulation on the floor of upstairs rooms instead of carpet.
I had a relative who rarely had the heating on and lived mainly downstairs. When he went into a care home, I found all the clothes in the wardrobe of one bedroom were formed into a solid block by the growth of mould in the cupboard. I had to wear protective clothing, a mask and spread dust sheets on the floor in order to take them out stuff them into bags, seal them and take them to the tip.