Maybe have an initial talk with her and DON'T bring up her partner, his mother, etc. or she may feel that he is being attacked and automatically leap to defend him. Maybe arrange to spend sometime with her and then tell her that you're worried about her, and hope that she can reassure you? Maybe start with something like you always thought she wanted children and now that she's 34, you'wondering if she is content that she may never have them? And then see what her reaction is, and go from there? Reassure her that you don't want to tell her what to do with her life, you just need her to confirm that she doesn't want children - and then you can stop worrying. If she takes it from you and it becomes clear that she does want them, then you can change tack to discuss that most women's fertility declines quite sharply after 35? (But, of course, her partner can continue to have children for decades). If she doesn't want to discuss it, then leave it (because, even if she doesn't, then you may well trigger some reflection later on when she's on her own?) I think you're absolutely right to bring this up - in a kind, caring way. Too often, women get caught up in other people's dramas and their own needs are put on "the back burner". You need to make sure that hers are not. Good luck.