Alzheimer’s linked with PPI use.

Marydoll, it's horrible isn't it.

Pepper59

It's the only thing that helps with my acid reflux/ GORD. If I'd to spend all my time worrying about the side effects of all my varying medicines, I'd never take anything.

Me too. My life would be miserable without it. Coughing, vomiting, no thanks!

If I worried about all the side effects of my meds (all 20 of them) and stopped taking them, I wouldn't be here to write this post.

Espee, thanks for highlighting this, but I have no other choice.

Thank you growstuff Your reference was to the text of the article rather than the press release, which was a bit over my head.

However I scanned through it and I quote the first pararaph of the closing discussion of this report

We evaluated the risk of PPI use and the incidence of AD and other types of dementia in a community-based retrospective cohort. We considered at least a five-year lag window between the start of PPI usage and the incidence of any type of dementia. Our data analysis demonstrated no association between the use of PPIs and incidence of AD and a discretely increased risk of non-AD dementias after adjusting for comorbidities.

Alzheimers accounts for up to 70%of all dementias
I cannot say that I would be worrying myself unduly about the results of this research. Nothing for anyone to lose any sleep over

Esspee with respect, once again you seem concerned by adverse medication stats.

PPIs are also associated with Vitamin B12 deficiency. The blood levels might be OK, but PPIs reduce absorption of B12.

M0nica

Did the press report that was issued have the basic stats in?

www.nature.com/articles/s41598-020-78199-0

Did the press report that was issued have the basic stats in?

Was going to link the article MOnica but you have to register and tbh can’t be bothered.

Exactly what are the precise figures behind this current scare? To often these figures reach us through journalists and sub-editors who are looking for a shock horror story rather than a correct interpretation of the figures

If 30% of people in the relevant age group will develop dementia and the figure is 10% higher among those on these drugs. You are not talking about the the figure going from 30% to 40%, we are talking about 30% going up by 10% of 30%, that is from 30% to 33%.

This is why I like to see the figures.So has anyone seen the exact figures either in a press report or read the article so that we know what we are discussing.

Thanks Esspee thé Nature one said no great increase.
I can’t take a PPI for my hernia/reflux as it lowers my sodium, which I’m pre disposed towards. I’m not going to check the long term possibilities for the histamine H I take instead.

Jaxjacky

Was it the one in Nature Esspee?

New PPI Data Again Link Medication Use To Alzheimer's - Medscape - Apr 01, 2022.
Abdullah Hashmi.

I take it too.
Otherwise I wake up vomiting up stomach acid.

It's the only thing that helps with my acid reflux/ GORD. If I'd to spend all my time worrying about the side effects of all my varying medicines, I'd never take anything.

I take an antihistamine every day but remember a few years ago reading that the development of Alzheimer’s was connected with long-term use. It seems to depend on which report you read.

When they were first developed ( in Sweden I believe) they were never meant to be used long term.

I no longer take much notice after having worried myself sick about other medication being associated with the development of various conditions.

Was it the one in Nature Esspee?