I second Oops. Please go and see your doctor now. It sounds like you’re totally overwhelmed, and need to tidy up your mind, if you know what I mean.
In the meantime....why not book your holiday....with single beds. Perhaps even your own rooms, if that’s possible. It may put something back into your marriage, that has been missing. At least it’s worth a try.
Then, hopefully, you’ll start to feel stronger...mentally and physically, and you’ll be in a better place to help your son. All is not lost, because you’re estranged from your daughter. You’re just not ready to tackle that yet.
Just take small steps, and don’t try to do everything at once. Like I said....a tidy mind.
GP first...tomorrow. I wish you all the best. ?