This is info from the Mayo Clinic in the US.
Although PPIs have had an encouraging safety profile, recent studies regarding the long-term use of PPI medications have noted potential adverse effects, including risk of fractures, pneumonia, Clostridium difficile, diarrhea, hypomagnesemia, vitamin B12 deficiency, chronic kidney disease, and dementia.
1 Feb 2018
Proton Pump Inhibitors: Review of Emerging Concerns - Mayo ...
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