I'd had a number of negative blood tests for inflammatory arthritis after the birth of my last child. My hands became hot and swollen around fingers and joints, wrists and hands weak so I struggled to open bottles, hold the steering wheel. One morning, I woke and couldn't move, I eventually rolled out of bed, but my legs were very weak. 8 years later, I developed inflammatory eye disease and the GP I saw on that occasion has a special interest in arthritis/rheumatology. He and the rheumatologist he referred me to both said negative blood tests with positive symptoms should have led to a referral years earlier. Evidently, a flare up after pregnancy is classic. A family history was taken which confirmed I had the genetic base and glandular fever in my 20's left my immune system compromised so the RA took off.
Galen will be more up to date after the lecture,but so far as I'm concerned, things are improving. The newer drugs are wonderful, though of course not risk free, in fact they are risky. I've had one bad reaction but the last 2 years have had more energy and less pain/stiffness than for the previous many years. That's down to disease modifiers - for which I am grateful