Oh dear OP ...
As children - grown up children, we can still take our parents woefully for granted, but sometimes they enable that in us too ... I can look back on a time when my parents looked after my DD1 5 days a week - and I didn't say 'thank you' even nearly enough, or wonder if it was a bit much for them - but then /I thought they would have said if it was ... I somehow thought that it was a privilege for them and that made it ok - after all, they did say 'YES'. HOWEVER, if my mum and dad had said 'Actually...we can't manage that, " I think I would not have resented them and would just have made other arrangements.
I hope you can find the words to explain that as you get older, especially having already given so much time to supporting your family, you really need - not just 'deserve', but NEED time for yourselves. Whether it is an out and out 'Sorry, but no' to their request, or you offer some help, they need to know your boundary and you need to set it. I don't think it will be the end of the world for them ...